Sale had missed the past two weeks with inflammation in his pitching shoulder. Red Sox manager Alex Cora said Saturday that the All-Star left-hander could throw 100 pitches against Baltimore if he is not rusty.
To make room for Sale on the roster, the Red Sox optioned right-hander Brandon Workman to Triple-A Pawtucket.
Sale, 29, is 11-4 with an American League-best 2.04 ERA in 22 starts this season. He is tied for third in the majors with 207 strikeouts.