Ohtani did it with a single in the seventh inning off Tampa Bay reliever Hunter Wood. That followed a three-run home run in the first, a double in the third and a triple in the fifth.
Ohtani joins Jorge Polanco as the only players to hit for the cycle this season. He is the first Japanese-born player to accomplish the feat in major league history.
Ohtani is the seventh different Angels player to hit for the cycle and the first since Mike Trout in 2013.
Ohtani is only the sixth player in MLB history to hit for the cycle as a DH, the last being Jeff DaVanon (also for the Angels) in 2004.